Amabala eTransdermal afumana ukuthandwa njengendlela yokuhanjiswa kweziyobisi.Ngokungafaniyo neendlela eziqhelekileyo zokuthatha amayeza ngomlomo, amabala e-transdermal avumela ukuba iziyobisi zidlule ngokuthe ngqo eluswini zingene egazini.Le ndlela intsha yokuhanjiswa kweziyobisi ibe nempembelelo enkulu kwihlabathi lezonyango, kwaye ziye zasebenza ngempumelelo kwiminyaka yakutshanje.Kweli nqaku, sihlolisisa ntoniiipatches transdermalzikho kwaye zenziwe njani.
Iziseko zeIiPatches zeTransdermal
Amabala e-Transdermal ngamabala amancinci ahamba esikhumbeni.Ziqulethe iyeza elithi kancinane likhutshwe eluswini lingene egazini.I-patch inemigangatho emine esisiseko: i-backing layer, i-membrane layer, i-drug reservoir layer, kunye ne-adhesive layer.I-backing layer isebenza njengesithintelo esikhuselayo, ngelixa i-reservoir layer yeziyobisi iqulethe ichiza.I-adhesive layer igcina i-patch ikhuselekile, ngelixa ifilimu ilawula izinga lokukhutshwa kwechiza.
Zeziphi izithako kwiipetshi ze-transdermal?
Iipetshi zeTransdermal ziqulethe uluhlu lwezithako, kuxhomekeke kwiyeza ezihambisayo.Nangona kunjalo, ezinye zezona zithako zixhaphakileyo ziquka iikhompawundi zamayeza, iipolymers, izixhasi zokungena, izibophelelo, kunye nezinyibilikisi.Ikhompawundi yamachiza sisithako esisebenzayo esibonelela iyeza.Iipolymers, kwelinye icala, zisetyenziswa kwinkqubo yokwenziwa kwemveliso ukwenza iileyiti zogcino lweziyobisi.Izixhasi zokungena zongezwa ukunyusa izinga lokukhutshwa kwechiza.I-Adhesives isetyenziselwa ukuqinisekisa ukuba i-patch igcinwe ngokukhuselekileyo, ngelixa i-solvents isetyenziselwa ukunyibilikisa i-compound yeziyobisi kunye nokunceda kwinkqubo yokuvelisa.
Inkqubo yokwenziwa kwemvelisoiipatches transdermal
Inkqubo yokwenziwa kweepatches ze-transdermal yinkqubo enzima ebandakanya izigaba ezininzi.Inqanaba lokuqala libandakanya ukulungiselela i-backing layer, ngokuqhelekileyo yenziwe ngefilimu yeplastiki.Inqanaba elilandelayo libandakanya ukulungisa i-reservoir layer yeziyobisi, equkethe i-polymer matrix equlethe isithako esisebenzayo.Umaleko wereservoir yeziyobisi ulaminethiwe kwi-backing layer.
Emva kokuba umaleko we-reservoir weziyobisi ulaminelwe kwi-backing layer, i-adhesive layer isetyenziswa.Umaleko wokuncamathelisa ngokwesiqhelo uqulathe incamathela encamathelayo ngoxinzelelo esetyenziswa kumqolo obhityileyo kusetyenziswa inkqubo yokwaleka isisombululo.Inqanaba lokugqibela libandakanya ukusetyenziswa kwenwebu ye-membrane, ngokuqhelekileyo yenziwe nge-semi-permeable okanye i-microporous material.Umaleko wefilimu ulawula isantya apho iyeza likhutshwa kwipetshi.
Ukuququmbela,iipatches transdermalziye zaliguqula ishishini lezonyango, zibonelela ngendlela entsha yokuhambisa amayeza.Inkqubo yokulungiselela ama-patches e-transdermal iyinkimbinkimbi kwaye ibandakanya izigaba ezininzi, kubandakanywa ukulungiswa kwe-backing layer, i-drug reservoir layer, i-adhesive layer kunye ne-film layer.Nangona iipatches ze-transdermal ziqulethe iintlobo zezithako, kubandakanywa iikhompawundi zamachiza, iipolymers, izibophelelo kunye nezinyibilikisi, impumelelo yabo ixhomekeke ekukwazini ukuhambisa iziyobisi ngokuthe ngqo kwigazi, okwenza kube yindlela yokuhanjiswa kweziyobisi yokuzikhethela kwabaninzi.Ukuveliswa kweepatches ze-transdermal ngokungathandabuzekiyo kuya kuba phambili ngakumbi njengoko iteknoloji ihambela phambili, ibenza ibe sisixhobo esibaluleke kakhulu ekuhanjisweni kwamachiza.
Ixesha lokuposa: May-16-2023